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Human CellExp™ TPBG, Human Recombinant

Supplier:
Catalogue number:
P1553-10
Size:
10 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£160.00 Estimated delivery Wed 30 Jun
Shipping is calculated in checkout

Trophoblast glycoprotein, also known as TPBG or 5T4, is a human cell surface protein encoded by a TPBG gene and an antagonist of the of Wnt/β-catenin signaling pathway. TPBG/5T4 is rarely expressed in normal adult tissues, but is present at high levels in placenta and in most common tumors, typically more than 80% of carcinomas of the kidney, breast, colon, prostate, and ovary. Due to its selective expression, it is often used as a prognostic aid in cancer cases. Recently, it has been shown that TPBG inhibits Wnt/β-catenin signaling, a signaling system central to many developmental and pathological processes and therefore serves as a therapeutic target of several anticancer agents currently in clinical development.

Product Type:

Proteins and peptides

Alternative Names:

Trophoblast glycoprotein, 5T4 oncofetal antigen, 5T4 oncofetal trophoblast glycoprotein, 5T4 oncotrophoblast glycoprotein, M6P1, Wnt-activated inhibitory factor 1, WAIF1,TPBG

Storage Temp:

-20°C

Molecular Weight:

36.56-

UNSPSC Code:

12352202

Human CellExp™ TPBG, Human Recombinant

Human CellExp™ TPBG, Human Recombinant

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