Receptor activator of nuclear factor kappa-B ligand (RANK-L), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11) or CD254, is a member of the tumor necrosis factor (TNF) superfamily. Receptor activator of nuclear factor kappa-B ligand (RANK) and its ligand RANKL have been described for their key roles in bone metabolism, the central nervous system and the immune system. Subsequently, it has been shown that the RANKL-RANK system also plays a critical role in other bone pathologies, bone metastasis or hormone-driven breast cancer. RANK-L is a ligand for osteoprotegerin (OPG) and functions as a key factor for osteoclast differentiation and activation. Some studies suggest the expression of RANK-L allows sufficient microenvironmental conditions to influence cancer cell migration.
Proteins and peptides
TNSF11, CD254, tumor necrosis factor ligand superfamily member 11, osteoclast differentiation factor, osteoprotegerin ligand, receptor activator of nuclear factor kappa-B ligand, TNF-related activation-induced cytokine