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Recombinant SARS-CoV-2 Papain-like Protease

Supplier:
Catalogue number:
P1551-50
Size:
50 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£632.00 Estimated delivery Wed 23 Jun
Shipping is calculated in checkout

SARS-CoV is an enveloped, single and positive-stranded RNA virus. Replication of the genomic RNA of SARS-CoV is mediated by replicase polyproteins that are processed by two viral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro). The chymotrypsin-like 3CLpro processes the replicase polyprotein at 11 sites, including cleaving itself from the polyprotein to generate a ∼25-kDa protease product. Papain-like proteases have been shown to process the amino-terminal end of the replicase polyprotein to generate two or three replicase products. Proteolytic processing of the coronavirus replicase polyprotein is essential for generating a functional replication complex. Therefore, the coronavirus replicase-encoded proteases, 3CLpro and PLpro, are potential targets for antiviral drug development.

Product Type:

Proteins and peptides

Alternative Names:

PLPro, PL-PRO, pp1a, Papain-like Protease, Replicase polyprotein 1a, ORF1a polyprotein, Plpro

Storage Temp:

-80°C

Molecular Weight:

386-

UNSPSC Code:

12352202

Recombinant SARS-CoV-2 Papain-like Prote

Recombinant SARS-CoV-2 Papain-like Protease

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