Hepatitis C virus (HCV) is a major cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. The HCV core protein is highly basic that forms the nucleocapsid and interacts with RNA. The protein contains three different domains. The N-terminus of the protein (amino acid 1-120) forms the hydrophilic domain which necessary for homo-oligomerisation and forming the nucleocapsid. While the other domains contain are hydrophobic and interacts with the endoplasmic reticulum membranes. This is a soluble form of the protein, which can be used for ELISA and Western Blot positive controls.
Proteins and peptides
Capsid protein, HCV Core Protein