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CAS Number:
303997-35-5
Purity:
≥98%
Molecular Weight:
380
Alternative Names:
TNF-alpha Antagonist III; 8-chloro-4-phenylsulfanyl-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline; 8-chloro-1-(trifluoromethyl)[1,2,4]triazolo[4,3-a]quinoxalin-4-yl phenyl sulfide
- Data sheet: View or download
- MSDS: View or download
Product Description:
R-7050 is a cell-permeable inhibitor of signaling through the TNFα receptor (TNFαR) complex. It blocks the formation of signal-initiating complexes that consist of TNFα receptor (TNFαR) I, TNFαR associated death domain protein (TRADD) and receptor interacting protein 1 (RIP1) through inhibition of ligand-induced receptor endocytosis. It inhibits TNFα-induced intercellular adhesion molecule 1 (ICAM-1) expression with an EC₅₀ of 0.631 µM. It (6-12 mg/kg) improves neurovascular injury after intracerebral hemorrhage in mice.
Storage Temperature:
-20°C
