www.bioscience.co.uk
Sales & Support: +44 (0)1223 316 855

*

Siramesine

Supplier:
Catalogue number:
B3053-1
Size:
1 mg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£109.00 Estimated delivery Wed 23 Jun
Shipping is calculated in checkout

Siramesine is an agonist for sigma-2 (σ2) receptor. It is selective for σ2 over σ1 with IC₅₀ values of 0.12 nM and 17 nM respectively. It shows potent anxiolytic-like effects in rodents. The minimal effective dose (MED) is 0.18 nmol/kg (0.1 microg/kg) and 0.00018 nmol/kg (0.1 ng/kg) in rats and mice respectively. It (20-30 µM) induces cell death in HaCaT, Hsc-4, HeLa, MCF-7, SH-SY5Y and glioblastoma cell lines. Siramesine shows anti-viral activity againt SARS-CoV-2 infection in the Vero E6 cell line in an immunofluorescence-based assay (detecting the viral NP protein).

Product Type:

Biochemicals

CAS Number:

147817-50-3

Storage Temp:

-20°C

Compound Purity:

≥98%

Molecular Weight:

454.6

UNSPSC Code:

12352200

Siramesine

Siramesine

Details Cat number & supplier Size Price
Omeprazole B3052-500 · BioVision
B3052-500
BioVision
500 mg £77.00
500 mg
view
Siramesine B3053-5 · BioVision
B3053-5
BioVision
5 mg £428.00
5 mg
view
Omeprazole B3052-1000 · BioVision
B3052-1000
BioVision
1 g £135.00
1 g
view
FITC-Tyramide B3054-1000 · BioVision
B3054-1000
BioVision
1 mg £377.00
1 mg
view
RIPA-56 B3051-5 · BioVision
B3051-5
BioVision
5 mg £83.00
5 mg
view
FITC-Tyramide B3054-500 · BioVision
B3054-500
BioVision
500 µg £224.00
500 µg
view
RIPA-56 B3051-25 · BioVision
B3051-25
BioVision
25 mg £332.00
25 mg
view