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CAS Number:
1956370-21-0
Purity:
≥98%
Molecular Weight:
221
Alternative Names:
N-benzyl-N-hydroxy-2,2-dimethylbutanamide
- Data sheet: View or download
- MSDS: View or download
Product Description:
RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase with an IC₅₀ of 13 nM. It protects HT-29 cells against TNFα-induced necroptosis with an EC₅₀ of 28 nM. RIPA-56 efficiently reduces TNFα-induced mortality and multiorgan damage in a systemic inflammatory response syndrome (SIRS) mice model. Modulators of RIP kinase 1 may be beneficial against SARS-CoV-2 based on interaction of RIP kinase 1 with SARS-CoV-2 protein Nsp12.
Storage Temperature:
-20°C
