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PRE-084 Hydrochloride

Supplier:
Catalogue number:
B3049-25
Size:
25 mg
Product is available in:
  • UK
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£307.00 Estimated delivery Wed 23 Jun
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PRE-084 is a high affinity sigma receptor 1 (σ1) agonist. It shows Ki values of 2.2 and 13,091 nM for σ1 and σ2 receptors, respectively and an IC₅₀ of 44 nM in the sigma receptor assay. It does not show significant activity for PCP and other receptors (IC₅₀ > 10,000 nM). PRE-084 has beneficial effects in a cellular model of Huntington's disease. It (0.3 µM) decreases the deleterious effects of N-terminal mutant huntington proteins in neuronal PC6.3 cells by activating NF-κB pathway and decreasing oxidative stress. Modulators of sigma receptor 1 may be beneficial against SARS-CoV-2 based on interaction of sigma receptors with SARS-CoV-2 protein Nsp6.

Product Type:

Biochemicals

CAS Number:

75136-54-8

Storage Temp:

-20°C

Compound Purity:

≥98%

Molecular Weight:

353.88

UNSPSC Code:

12352200

PRE-084 Hydrochloride

PRE-084 Hydrochloride

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