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NE-100 hydrochloride

Supplier:
Catalogue number:
B3047-1
Size:
1 mg
Product is available in:
  • UK
  • Ireland
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  • Rest of World
£77.00 Estimated delivery Wed 23 Jun
Shipping is calculated in checkout

NE-100 is a potent antagonist of sigma-1 (σ1) receptor. It inhibits binding of (+)-pentazocine binding to sigma-1 binding sites with an IC₅₀ value of 1.54 nM. NE-100 attenuates phencyclidin induced head-weaving behavior or ataxia in experimental animals. It suppresses ER stress-induced cell death by the upregulation of 78-kDa glucose-regulated protein (GRP78). Modulators of sigma receptors are suggested to show activity against SARS-CoV-2, based on interaction of SARS-CoV-2 proteins Nsp6 and Orf9c with sigma receptors.

Product Type:

Biochemicals

CAS Number:

149409-57-4

Storage Temp:

-20°C

Compound Purity:

≥98%

Molecular Weight:

391.97

UNSPSC Code:

12352200

NE-100 hydrochloride

NE-100 hydrochloride

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