NE-100 hydrochloride
Catalogue number:
B3047-1
Supplier:
BioVision
Size:
1 mg _$$_
Product is available in:
N/A
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CAS Number:
149409-57-4
Purity:
≥98%
Molecular Weight:
391
Alternative Names:
N-[2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethyl]-N-propylpropan-1-amine;hydrochloride; 4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanamine hydrochloride
- Data sheet: View or download
- MSDS: View or download
Product Description:
NE-100 is a potent antagonist of sigma-1 (σ1) receptor. It inhibits binding of (+)-pentazocine binding to sigma-1 binding sites with an IC₅₀ value of 1.54 nM. NE-100 attenuates phencyclidin induced head-weaving behavior or ataxia in experimental animals. It suppresses ER stress-induced cell death by the upregulation of 78-kDa glucose-regulated protein (GRP78). Modulators of sigma receptors are suggested to show activity against SARS-CoV-2, based on interaction of SARS-CoV-2 proteins Nsp6 and Orf9c with sigma receptors.
Storage Temperature:
-20°C