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NE-100 hydrochloride

Catalogue number:
Supplier:
BioVision
Size:
1 mg _$$_
Product is available in:
  • UK
  • Ireland
  • Europe
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  • Rest of World
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CAS Number:

149409-57-4

Purity:

≥98%

Molecular Weight:

391

Alternative Names:

N-[2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethyl]-N-propylpropan-1-amine;hydrochloride; 4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanamine hydrochloride

Product Description:

NE-100 is a potent antagonist of sigma-1 (σ1) receptor. It inhibits binding of (+)-pentazocine binding to sigma-1 binding sites with an IC₅₀ value of 1.54 nM. NE-100 attenuates phencyclidin induced head-weaving behavior or ataxia in experimental animals. It suppresses ER stress-induced cell death by the upregulation of 78-kDa glucose-regulated protein (GRP78). Modulators of sigma receptors are suggested to show activity against SARS-CoV-2, based on interaction of SARS-CoV-2 proteins Nsp6 and Orf9c with sigma receptors.

Storage Temperature:

-20°C

NE-100 hydrochloride
NE-100 hydrochloride