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GBR-12909

Catalogue number:
Supplier:
BioVision
Size:
25 mg _$$_
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
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CAS Number:

67469-69-6

Purity:

≥98%

Molecular Weight:

450

Alternative Names:

Vanorexine; Vanoxerin; 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine; Vanoxerina; Vanoxerinum

Product Description:

GBR-12909 is a potent and selective inhibitor of dopamine uptake (Ki = 1 nM). It inhibits dopamine uptake in tissue slices obtained from rat neostriatum at nanomolar concentrations. GBR-12909 (10 mg/kg IP) produces a dose-dependent decrease in the binding of cocaine to the dopamine transporter in rats. It antagonizes the ability of cocaine to elevate extracellular dopamine. It is also a potent blocker of cardiac hERG, sodium and calcium channels and shows cardiac antiarrhythmic properties. It is a potent ligand for sigma receptor. Regulators of sigma receptors are suggested to show activity against COVID-19, based on viral assay screens

Storage Temperature:

-20°C

GBR-12909
GBR-12909