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Tafamidis

Supplier:
Catalogue number:
B3035-5
Size:
5 mg
Product is available in:
  • UK
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£77.00 Estimated delivery Wed 23 Jun
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Tafamidis is a potent kinetic stabiliser of transthyretin (TTR). Tafamidis binds selectively and with negative cooperativity (Kd values ∼2 nM and ∼200 nM) to the two normally unoccupied thyroxine-binding sites of the tetramer and kinetically stabilises TTR. It prevents tetramer dissociation, the rate-limiting step in TTR misfolding and amyloidogenesis. Tafamadis also binds and stabilises patient-derived amyloidogenic variants of TTR, including kinetically and thermodynamically less stable mutants. It is approved for the treatment of cardiomyopathy caused by transthyretin mediated amyloidosis in adults.

Product Type:

Biochemicals

CAS Number:

594839-88-0

Storage Temp:

-20°C

Compound Purity:

>98%

Molecular Weight:

308.1

UNSPSC Code:

12352200

Tafamidis

Tafamidis

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