1446321-46-5
≥98%
337
Voxelotor; Hemoglobin Modulators-1; 2-hydroxy-6-[[2-(2-propan-2-ylpyrazol-3-yl)pyridin-3-yl]methoxy]benzaldehyde; 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde; 2-hydroxy-6-((2-(1-(propan-2-yl)-1H-pyrazol-5-yl)pyridin-3-yl
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- MSDS: View or download
GTB-440 is a modulator of sickle hemoglobin S (HbS). It binds to the N‐terminal valine of one of the haemoglobin α chains and increases HbS affinity for oxygen. GBT440 dose‐dependently increases HbS affinity for oxygen (EC₅₀ = 8·2 µM) for purified HbS and (EC₅₀ = 415 µM) for whole blood from sickle cell disease (SCD) patients. It delays in vitro HbS polymerization and prevents sickling of RBCs. In a murine model of SCD, GBT-440 (100 and 150 mg/kg for 9–12 d) increases the half‐life of RBCs, reduces reticulocyte counts and prevents ex vivo RBC sickling.
-20°C
