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Anti-CCR5 (Leronlimab), Humanized Antibody

Supplier:
Catalogue number:
A2181-100
Size:
100 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£581.00 Estimated delivery Wed 11 Aug
Shipping is calculated in checkout

The research-grade biosimilar is an investigational humanised IgG4 monoclonal antibody that specifically inhibits CCR5. CCR5 is a chemokine receptor that is expressed on the surface of a broad range of cells including T-cells, B-cells, and macrophages, and plays an important role in immune responses. Human Immunodeficiency Virus 1 (HIV-1) uses CCR5 as a co-receptor to enter and infect immunologic cells. The antibody binds to the hydrophilic extracellular domains of the CCR5 and competitively inhibits the CCR5-mediated HIV-1 entry into the host cells. The antibody does not target viruses using CXCR4 as a receptor to enter host cells. The original drug was granted Fast Track Designation by the US FDA to treat HIV infected patients in combination with HAART, and for metastatic triple-negative breast cancer. Currently, the drug is in early clinical trials to treat COVID-19 disease.

Product Type:

Antibodies

Species Reactivity:

Human

Storage Temp:

-80°C

Antibody Host:

Recombinant

Antibody Isotype:

IgG4, kappa

Formulation:

In PBS, pH 7.5

Antibody Type:

Monoclonal

UNSPSC Code:

12352203

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