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Anti-CD20 (Obinutuzumab), Humanized Antibody

Supplier:
Catalogue number:
A2180-100
Size:
100 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£581.00 Estimated delivery Wed 23 Jun
Shipping is calculated in checkout

The research-grade biosimilar is Type II humanised monoclonal antibody that targets CD20 expressed on pre- and mature B lymphocyte cells. The antibody is glycoengineered to increase the binding of CD 64 and CD16 by 7-10 folds and improve antibody-dependent cellular cytotoxicity (ADCC). Additionally, the glycoengineered structure of the antibody helps recruit immune effector cells such as polymorphonuclear neutrophils (PMNs), which when activated, release inflammatory mediators, and promote phagocytosis. A previous study demonstrated that the binding of the antibody to CD20 causes rearrangement of the actin cytoskeleton, which causes the lysosomal compartment to expand. As a result, the lysosomal membrane becomes permeable, causing Cathepsin B to leak into the cytosol. Excessive leakage of Cathepsin B promotes cell death by necrosis. The original drug has been approved by the FDA to treat patients with chronic lymphocytic leukemia (CLL) in combination with Chlorambucil.

Product Type:

Antibodies

Species Reactivity:

Human

Storage Temp:

-80°C

Antibody Host:

Recombinant

Antibody Isotype:

IgG1, kappa

Formulation:

In PBS, pH 7.5

Antibody Type:

Monoclonal

UNSPSC Code:

12352203

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