www.bioscience.co.uk
Sales & Support: +44 (0)1223 316 855

*

Anti-CD22 (Inotuzumab Ozogamicin), Humanized Antibody

Supplier:
Catalogue number:
A2179-100
Size:
100 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£581.00 Estimated delivery Wed 23 Jun
Shipping is calculated in checkout

The research-grade biosimilar is an antibody-drug conjugate that is directed to CD22 which is highly expressed on the surface of B cells. The conjugate consists of Anti-CD22 humanised monoclonal antibody that is linked to a cytotoxic drug N-acetyl-gamma-calicheamicin via 4-(4 acetylphenoxy) butanoic acid (acetyl butyrate) linker. Upon internalisation in the cell, the drug is detached from the antibody by hydrolytic cleavage. The drug binds to the minor groove of the DNA and forms a diradical species. This diradical species abstracts hydrogen ions from the phosphodiester bonds of DNA and causes double-strand DNA breaks, which leads to cell cycle arrest and apoptosis of the tumorigenic cells. The original antibody-drug conjugate is approved by the FDA to treat acute myeloid leukemia. It is also approved to treat adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL).

Product Type:

Antibodies

Species Reactivity:

Human

Storage Temp:

-80°C

Antibody Host:

Recombinant

Antibody Isotype:

IgG4, kappa

Formulation:

In PBS, pH 7.5

Antibody Type:

Monoclonal

UNSPSC Code:

12352203

Details Cat number & supplier Size Price
Anti-CD79B (Polatuzumab Vedotin), Humanized Antibody A2178-100 · BioVision
A2178-100
BioVision
100 µg £581.00
100 µg
view
Anti-CD20 (Obinutuzumab), Humanized Antibody A2180-100 · BioVision
A2180-100
BioVision
100 µg £581.00
100 µg
view
Anti-CD30 (Brentuximab Vedotin), Chimeric Antibody A2177-100 · BioVision
A2177-100
BioVision
100 µg £581.00
100 µg
view
Anti-CCR5 (Leronlimab), Humanized Antibody A2181-100 · BioVision
A2181-100
BioVision
100 µg £581.00
100 µg
view
Anti-Nectin-4 (Enfortumab Vedotin), Human IgG1 Antibody A2176-100 · BioVision
A2176-100
BioVision
100 µg £581.00
100 µg
view
Anti-TROP2 (Sacituzumab Govitecan), Humanized Antibody A2175-100 · BioVision
A2175-100
BioVision
100 µg £581.00
100 µg
view
Anti-IL23α (Mirikizumab), Humanized Antibody A2174-100 · BioVision
A2174-100
BioVision
100 µg £581.00
100 µg
view