Anti-CD30 (Brentuximab Vedotin), Chimeric Antibody
Catalogue number:
A2177-100
Supplier:
BioVision
Size:
100 µg _$$_
Product is available in:
N/A
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Antibody Host:
Human/Mouse chimeric
Species Reactivity:
Human
Antibody Isotype:
IgG1, kappa
Antibody Type:
Monoclonal
Immunogen:
Human CD30
- Data sheet: View or download
Product Description:
The research-grade biosimilar is an antibody-drug conjugate that targets CD30. The conjugate consists of an Anti-CD30 human-mouse chimeric IgG1 antibody that is linked to a microtubule disrupting agent monomethyl auristatin E (MMAE) via a protease-cleavable linker. Upon internalization in the cell, the MMAE is detached from the antibody due to proteolytic cleavage. The MMAE then disrupts the microtubule network, which causes cell cycle arrest and results in apoptosis of tumorigenic cells. The original drug received approval from the FDA to treat adult patients with relapsed or refractory Hodgkin’s lymphoma and systemic anaplastic large cell lymphoma.
Storage Temperature:
-80°C