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Anti-Nectin-4 (Enfortumab Vedotin), Human IgG1 Antibody

Supplier:
Catalogue number:
A2176-100
Size:
100 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£581.00 Estimated delivery Wed 11 Aug
Shipping is calculated in checkout

The research-grade biosimilar is an antibody-drug conjugate that targets Nectin-4, which is highly expressed in urothelial cancers. The original conjugate comprises an anti-Nectin-4 human monoclonal antibody that is chemically linked to a microtubule disrupting drug, monomethyl auristatin E (MMAE) via a protease-cleavable linker. Upon internalisation in the cell, the MMAE is detached from the antibody due to proteolytic cleavage. The MMAE then disrupts the microtubule network, arrests cell cycle, and induces apoptosis. The original drug conjugate is approved by the FDA to treat metastatic bladder cancer patients, who were previously treated with platinum-containing chemotherapy, or PD-1/PD-L1 checkpoint inhibitors

Product Type:

Antibodies

Species Reactivity:

Human

Storage Temp:

-80°C

Antibody Host:

Recombinant

Antibody Isotype:

IgG1, kappa

Formulation:

In PBS, pH 7.5

Antibody Type:

Monoclonal

UNSPSC Code:

12352203

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