www.bioscience.co.uk
Sales & Support: +44 (0)1223 316 855

*

Anti-CD20 (Ofatumumab), Human IgG1 Antibody

Supplier:
Catalogue number:
A2172-100
Size:
100 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£530.00 Estimated delivery Wed 30 Jun
Shipping is calculated in checkout

The research-grade biosimilar is a human IgG1 kappa monoclonal antibody that acts as a CD20 antagonist. CD20 is usually expressed on pre- and mature B lymphocytes, as well as malignant B lymphocytes. The Fab domain of the antibody binds to the large and small extracellular loops of the CD20 molecule but does not cause immediate shedding and internalisation of CD20. Instead, the binding persists on B cell surface for an extended time, which helps recruit innate effectors such as macrophages that induce complement-dependent and antibody-dependent cellular cytotoxicity and cause B cell lysis. The original drug was approved by the FDA to treat progressive or recurrent chronic lymphocytic leukemia (CLL), or in CLL patients who were refractory to fludarabine-based therapy

Product Type:

Antibodies

Species Reactivity:

Human

Storage Temp:

-80°C

Antibody Host:

Recombinant

Antibody Isotype:

IgG1, kappa

Formulation:

In PBS, pH 7.5

Antibody Type:

Monoclonal

UNSPSC Code:

12352203

Details Cat number & supplier Size Price
Anti-ANGPTL3 (Evinacumab), Human IgG4 Antibody A2171-100 · BioVision
A2171-100
BioVision
100 µg £581.00
100 µg
view
Anti-CD19 (Inebilizumab), Humanized Antibody A2173-100 · BioVision
A2173-100
BioVision
100 µg £581.00
100 µg
view
Anti-TNSF13B (Belimumab), Human IgG1 Antibody A2170-100 · BioVision
A2170-100
BioVision
100 µg £581.00
100 µg
view
Anti-IL23α (Mirikizumab), Humanized Antibody A2174-100 · BioVision
A2174-100
BioVision
100 µg £581.00
100 µg
view
Anti-Dabigratan (Idarucizumab), Humanized Antibody A2169-100 · BioVision
A2169-100
BioVision
100 µg £581.00
100 µg
view
Anti-TROP2 (Sacituzumab Govitecan), Humanized Antibody A2175-100 · BioVision
A2175-100
BioVision
100 µg £581.00
100 µg
view
Anti-PCSK9 (Evolocumab), Human IgG2 Antibody A2168-100 · BioVision
A2168-100
BioVision
100 µg £581.00
100 µg
view