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Anti-ANGPTL3 (Evinacumab), Human IgG4 Antibody

Supplier:
Catalogue number:
A2171-100
Size:
100 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£581.00 Estimated delivery Wed 23 Jun
Shipping is calculated in checkout

The research-grade biosimilar is an investigational human monoclonal antibody that targets angiopoietin-like 3 inhibitor (ANGPTL3). ANGPTL3 is primarily expressed in the liver and it inhibits LPL activity and endothelial lipase activity. This prevents the clearance of lipids and raises the concentration of triglycerides and LDL-C in the blood. The antibody binds with high affinity and specificity to ANGPTL3 and reverses the inhibitory action on LPL, thus promoting the clearance of LDL-C from the blood. The original drug was awarded breakthrough therapy designation by the FDA to treat patients suffering from homozygous familial hypercholesterolemia (HoFH).

Product Type:

Antibodies

Species Reactivity:

Human

Storage Temp:

-80°C

Antibody Host:

Recombinant

Antibody Isotype:

IgG4, kappa

Formulation:

In PBS, pH 7.5

Antibody Type:

Monoclonal

UNSPSC Code:

12352203

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