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Anti-TNSF13B (Belimumab), Human IgG1 Antibody

Supplier:
Catalogue number:
A2170-100
Size:
100 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£581.00 Estimated delivery Wed 23 Jun
Shipping is calculated in checkout

The research-grade biosimilar is a recombinant fully human IgG1 monoclonal antibody that specifically binds to soluble human B lymphocyte stimulator protein (BLyS), also known as B-cell activating factor (BAFF). BAFF belongs to the superfamily of Tumor Necrosis Factor (TNF) and plays a vital role in B-cell maturation and survival. It is produced by several cell types such as neutrophils, dendritic cells, and macrophages. Binding of BLyS to its receptors on the surface of B-cells activates downstream signaling pathways such as NF-κB and MAPK pathways that promote the expression of anti-apoptotic proteins and inhibit apoptosis. The antibody binds to BLyS, prevents the association with its receptors, and thereby reduces the survival of autoantibody-producing B-cells. The original drug received approval from the FDA to treat systemic lupus erythematosus.

Product Type:

Antibodies

Species Reactivity:

Human

Storage Temp:

-80°C

Antibody Host:

Recombinant

Antibody Isotype:

IgG1, lambda

Formulation:

In PBS, pH 7.5

Antibody Type:

Monoclonal

UNSPSC Code:

12352203

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