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Anti-Dabigratan (Idarucizumab), Humanized Antibody

Supplier:
Catalogue number:
A2169-100
Size:
100 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£581.00 Estimated delivery Wed 23 Jun
Shipping is calculated in checkout

The research-grade biosimilar antibody is a humanised monoclonal antibody fragment that specifically neutralises the anti-coagulatory effect of dabigatran. Dabigatran is a non-peptidic inhibitor of thrombin (Factor IIa) that plays an important role in blood coagulation. Dabigatran and its acyl glucuronide metabolites bind reversibly with thrombin and inhibit its coagulatory activity. The antibody binds to thrombin-bound dabigatran and its metabolites in a 1:1 ratio with very high affinity (≈ 350-fold higher than dabigatran affinity for thrombin) and thus prevents thrombin inhibition. The original drug was approved by the FDA to treat patients requiring emergency surgery or having an uncontrolled bleeding condition

Product Type:

Antibodies

Storage Temp:

-80°C

Antibody Host:

Recombinant

Antibody Isotype:

Fab - G1 - kappa

Formulation:

In PBS, pH 7.5

Antibody Type:

Monoclonal

UNSPSC Code:

12352203

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