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Anti-IL-5Rα (Benralizumab), Humanized Antibody

Supplier:
Catalogue number:
A2162-100
Size:
100 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£581.00 Estimated delivery Wed 23 Jun
Shipping is calculated in checkout

The research-grade biosimilar is a humanised IgG1 monoclonal antibody that selectively binds to isoleucine 61 amino acid residue in the domain 1 of IL-5Rα. Binding of the antibody prevents the interaction of IL-5 with the receptor and heterodimerisation of α and βc subunits, thus inhibiting IL-5 mediated signaling. Additionally, the antibody binds via its Fc constant region to the FcγIIIRa receptor located on the surface of NK cells and thus induces eosinophil apoptosis via the release of proapoptotic proteins such as granzyme B and perforins. The original drug received FDA approval in 2017 to treat severe eosinophilic asthma. The US FDA also granted orphan drug designation to this drug in 2019 for the treatment of eosinophilic esophagitis

Product Type:

Antibodies

Species Reactivity:

Human

Storage Temp:

-80°C

Antibody Host:

Recombinant

Antibody Isotype:

IgG1, kappa

Formulation:

In PBS, pH 7.5

Antibody Type:

Monoclonal

UNSPSC Code:

12352203

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