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Anti-IGF-1R (Teprotumumab), Human IgG1 Antibody

Supplier:
Catalogue number:
A2160-100
Size:
100 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£581.00 Estimated delivery Wed 30 Jun
Shipping is calculated in checkout

The research-grade biosimilar is a fully human IgG1 monoclonal antibody that binds to the α-subunit domain of IGF-1R. IGF-1R is overexpressed in orbital fibroblasts of patients suffering from thyroid eye disease. Thyroid eye disease is a manifestation of Grave’s disease that is associated with inflammation of orbital muscles and fatty tissues. Although the mechanism of action of the original drug has not yet been fully characterised, binding of the drug to IGF-1R has been reported to internalise and degrade the receptors, and thus inhibit tissue inflammation and remodeling associated with Thyroid eye disease. In 2020, the US FDA approved the application of the drug to treat Graves-associated ophthalmopathy

Product Type:

Antibodies

Species Reactivity:

Human

Storage Temp:

-80°C

Antibody Host:

Recombinant

Antibody Isotype:

IgG1

Formulation:

In PBS, pH 7.5

Antibody Type:

Monoclonal

UNSPSC Code:

12352203

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