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Anti-BRCA1 Antibody

Supplier:
Catalogue number:
A2157-100
Size:
100 µl
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£435.00 Estimated delivery Wed 23 Jun
Shipping is calculated in checkout

This gene encodes a 190 kDa nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localisation and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants have been described. A related pseudogene, which is also located on chromosome 17, has been identified.

  • Data sheet/protocol: View or download
  • Applications: Immunohistochemistry (IHC),Western Blotting
Product Type:

Antibodies

Species Reactivity:

Rat,Mouse,Human

Storage Temp:

-20°C

Antibody Host:

Rabbit

Antibody Isotype:

IgG

Formulation:

In 0.42% Potassium phosphate, 0.87% NaCl, pH 7.3, 30% glycerol, and 0.01% sodium azide

Antibody Type:

Polyclonal

UNSPSC Code:

12352203

Anti-BRCA1 Antibody

Anti-BRCA1 Antibody

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