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Anti-PD-1 (Sintilimab), Human IgG4 Antibody

Supplier:
Catalogue number:
A2156-100
Size:
100 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£581.00 Estimated delivery Wed 23 Jun
Shipping is calculated in checkout

The research-grade biosimilar is a fully human IgG4 monoclonal antibody that targets the human cell surface receptor programmed cell death-1 (PD-1), an immune checkpoint protein with neoplastic functions. The antibody binds to PD-1 and prevents the association with its ligands PD-L1 and PD-L2. This results in inhibition of PD-1 and its downstream signaling, leading to the activation of T-cells and T-cell mediated immune response to inhibit tumor growth. The original drug is approved in China to treat relapsed or refractory patients with classic Hodgkin’s lymphoma, after the second-line of chemotherapy. Currently, this drug is in the process of FDA approval for use in the United States. The drug is undergoing clinical trials to test for safety and efficacy in the treatment of cancers such as non-small cell lung cancer and esophageal cancer

Product Type:

Antibodies

Species Reactivity:

Human

Storage Temp:

-80°C

Antibody Host:

Recombinant

Antibody Isotype:

Human IgG4, kappa

Formulation:

In PBS, pH 7.5

Antibody Type:

Monoclonal

UNSPSC Code:

12352203

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