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Anti-TNF-α (Certolizumab), Humanized Antibody

Catalogue number:
Supplier:
BioVision
Size:
100 µg _$$_
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
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Antibody Host:

Fab-IgG1-kappa

Species Reactivity:

Human

Antibody Isotype:

Fab'-G1-kappa

Antibody Type:

Monoclonal

Immunogen:

Human TNF-α

Product Description:

The research-grade biosimilar is a humanized TNF-α monoclonal antibody. The original monoclonal antibody (Certolizumab pegol (CZP)) consists of polyethylene glycol conjugated to the antigen-binding fragment of the humanized monoclonal antibody. The antibody targets and neutralizes soluble and membrane forms of tumor necrosis factor-alpha (TNF-α) and inhibits TNF-α mediated signaling in vitro. Unlike other TNF inhibitors, this antibody does not contain the Fc region. As a result, decreased Fc-mediated effects such as antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) are observed. The original monoclonal antibody received FDA approval to treat moderate to severe rheumatoid arthritis, Crohn’s disease, ankylosing spondylitis, and psoriatic arthritis.

Storage Temperature:

-80°C