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Anti-TNF-α (Certolizumab Pegol), Humanized Antibody

Supplier:
Catalogue number:
A2142-100
Size:
100 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£581.00 Estimated delivery Wed 23 Jun
Shipping is calculated in checkout

Certolizumab pegol (CZP) is a polyethylene glycol conjugated antigen-binding fragment of a humanised TNF-α monoclonal antibody. This antibody targets and neutralises soluble and membrane forms of tumor necrosis factor alpha (TNF-α) and inhibits TNF-α mediated signaling in vitro. Unlike other TNF inhibitors, CZP does not contain the Fc region, which results in decreased Fc-mediated effects such as antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). CZP was developed by UCB Pharmaceuticals and received FDA approval for treatment of moderate to severe rheumatoid arthritis, Crohn’s disease, ankylosing spondylitis, and psoriatic arthritis. CZP is marketed under the trade name Cimzia®

Product Type:

Antibodies

Species Reactivity:

Human

Storage Temp:

-80°C

Antibody Host:

Recombinant

Antibody Isotype:

Fab'-G1-kappa

Formulation:

In PBS, pH 7.5

Antibody Type:

Monoclonal

UNSPSC Code:

12352203

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