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Anti-VEGFR2 (Ramucirumab), Human IgG1 Antibody

Supplier:
Catalogue number:
A2139-100
Size:
100 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£581.00 Estimated delivery Wed 30 Jun
Shipping is calculated in checkout

Ramucirumab is a fully human IgG1 monoclonal antibody that binds to the vascular endothelial growth factor receptor 2 (VEGFR2) and inhibits association with its ligands (VEGF A, C, and D). This prevents VEGF-mediated proliferation, migration of endothelial cells, and angiogenesis. Ramucirumab was developed by ImClone Systems and received FDA approval in 2014 for the treatment of advanced gastric cancer/gastro-esophageal junction (GEJ) adenocarcinoma. Recently, Ramucirumab has also been approved for use in combination treatment of metastatic non-small lung carcinoma (NSLC), metastatic colorectal cancer (mCRC), and hepatocellular carcinoma (HCC). Ramucirumab is currently marketed under the trade name CYRAMZA®.

Product Type:

Antibodies

Species Reactivity:

Human

Storage Temp:

-80°C

Antibody Host:

Human

Antibody Isotype:

IgG1, kappa

Formulation:

In PBS, pH 7.5

Antibody Type:

Monoclonal

UNSPSC Code:

12352203

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