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Anti-C5 (Eculizumab), Humanized Antibody

Supplier:
Catalogue number:
A2138-100
Size:
100 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£530.00 Estimated delivery Wed 23 Jun
Shipping is calculated in checkout

Eculizumab is a recombinant humanised IgG2/4 kappa monoclonal antibody that inhibits the cleavage of C5 into C5a and C5b by C5 convertases and prevents the generation of the terminal complement complex C5b-9. Both C5a and C5b-9 have proinflammatory and prothrombic properties and play a significant role in complement-mediated diseases such as paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). Eculizumab was developed by Alexion Pharmaceuticals and received FDA approval for the treatment of PNH and aHUS. Very recently, in the United States, this monoclonal antibody received approval for the treatment of adults suffering from general Myasthenia Gravis (gMG) but are anti-AChR antibody-positive. Eculizumab is marketed under the trade name (Soliris®)

Product Type:

Antibodies

Species Reactivity:

Human

Storage Temp:

-80°C

Antibody Host:

Recombinant

Antibody Isotype:

IgG2/4, kappa

Formulation:

In PBS, pH 7.5

Antibody Type:

Monoclonal

UNSPSC Code:

12352203

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