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Anti-IL-12β (Ustekinumab), Human IgG1 Antibody

Catalogue number:
Supplier:
BioVision
Size:
100 µg _$$_
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
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Applications:

In vitro studies

Antibody Host:

Recombinant

Species Reactivity:

Human

Antibody Isotype:

IgG1, kappa

Antibody Type:

Monoclonal

Immunogen:

Ustekinumab

Product Description:

The research-grade biosimilar is a human IgG1κ monoclonal antibody that was generated using human immunoglobulin (hu-Ig) transgenic mice. This monoclonal antibody specifically binds to the p40 subunit of IL-12 and IL-23, thus preventing their association with the IL-12Rβ1 receptor expressed on the NK cell and T cell surface and resulting in reduced IL-12 and IL-23 mediated signaling, activation, and cytokine production. The original monoclonal antibody was developed by Centocor and received FDA approval in 2009 for use in the treatment of psoriasis. Recently, it has been approved for the treatment of Crohn’s disease and ulcerative colitis.

Storage Temperature:

-80°C