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Anti-IL-6Rα (Sarilumab), Human IgG1 Antibody

Supplier:
Catalogue number:
A2133-100
Size:
100 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£607.00 Estimated delivery Wed 30 Jun
Shipping is calculated in checkout

Sarilumab (Kevzara) is a fully human anti-IL-6R monoclonal IgG1 antibody that can bind to membrane as well as soluble forms of interleukin 6 receptor (IL-6R). This leads to inhibition of IL-6 mediated signaling and reduced release of CRP, serum amyloid A and fibrinogen, which are potential biomarkers of rheumatoid arthritis (RA). This antibody was developed by Sanofi and Regeneron Pharmaceuticals and received US-FDA approval in 2017 to treat moderate to severe RA in combination with methotrexate. Sarilumab is currently being evaluated for phase 3 clinical trial on COVID-19 patients

  • Data sheet/protocol: View or download
  • Applications: In vitro and In vivo studies
Product Type:

Antibodies

Storage Temp:

4°C

Antibody Host:

CHO cells

Antibody Isotype:

Human IgG1

Formulation:

In PBS buffer, pH 7.2

Antibody Type:

Monoclonal

UNSPSC Code:

12352203

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