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Anti-PD-1 (Spartalizumab), Humanized Antibody

Supplier:
Catalogue number:
A2131-100
Size:
100 µg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£607.00 Estimated delivery Wed 23 Jun
Shipping is calculated in checkout

Spartalizumab is a humanized IgG4 monoclonal antibody developed by Novartis for the treatment of solid tumors as well as lymphomas. They act as negative immune regulators of programmed death-1 (PD-1), a transmembrane protein belonging to the immunoglobulin (Ig) superfamily. When administered, Spartalizumab binds to T-cells expressing PD-1 and thereby blocks the interaction between PD-1 and its ligands, programmed cell death 1 ligand 1 (PD-L1) and ligand 2 (PD-L2). Blocking the interaction disrupts PD-1 mediated signaling and results in activation of cytotoxic T lymphocytes and T cell mediated immune responses and thus inhibits the growth and size of the tumors. Ongoing clinical trials are evaluating the efficacy of this antibody for the treatment of metastatic pancreatic cancer and melanoma.

Product Type:

Antibodies

Storage Temp:

4°C

Antibody Host:

CHO cells

Antibody Isotype:

Human IgG4

Formulation:

In PBS buffer, pH 7.2

Antibody Type:

Monoclonal

UNSPSC Code:

12352203

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