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Anti-MEK2 (KO Validated) Antibody

Supplier:
Catalogue number:
A2124-100
Size:
100 µl
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£435.00 Estimated delivery Wed 23 Jun
Shipping is calculated in checkout

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterised by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Product Type:

Antibodies

Species Reactivity:

Mouse,Human

Storage Temp:

-20°C

Antibody Host:

Rabbit

Antibody Isotype:

IgG

Formulation:

In PBS with 0.02% sodium azide, 50% glycerol, pH 7.3

Antibody Type:

Monoclonal

UNSPSC Code:

12352203

Anti-MEK2 (KO Validated) Antibody

Anti-MEK2 (KO Validated) Antibody

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