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Anti-p21 (KO Validated) Antibody

Supplier:
Catalogue number:
A2120-100
Size:
100 µl
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£441.00 Estimated delivery Wed 30 Jun
Shipping is calculated in checkout

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene.

  • Data sheet/protocol: View or download
  • Applications: Immunohistochemistry (IHC),Western Blotting
Product Type:

Antibodies

Species Reactivity:

Human

Storage Temp:

-20°C

Antibody Host:

Rabbit

Antibody Isotype:

IgG

Formulation:

In PBS with 0.02% sodium azide, 50% glycerol, pH 7.3

Antibody Type:

Monoclonal

UNSPSC Code:

12352203

Anti-p21 (KO Validated) Antibody

Anti-p21 (KO Validated) Antibody

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