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TC-FPR 43

Catalogue number:
CAY29804-50 mg
Supplier:
Size:
50 mg _$$_
Product is available in:
  • UK
  • Ireland
  • Europe
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  • Rest of World
£1190.00 Estimated delivery Tue 9 Apr
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:

903895-98-7

Purity:

≥98%

Formulation:

A crystalline solid

Molecular Weight:

384.9

Alternative Names:

n-(4-chlorophenyl)-n′-[2,3-dihydro-1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-1h-pyrazol-4-yl]-urea, fpr agonist 43

Product Description:

An agonist of FPR1 and FPR2; induces calcium flux in CHO cells expressing human FPR2, Gα15, and aequorin (EC50 = 0.044 µM) and in CHO-K1 cells expressing either human FPR1, human FPR2, mouse Fpr1, or mouse Fpr2, Gα16, and aequorin in a concentration-dependent manner; inhibits fMLP- or IL-8-induced neutrophil migration (IC50s = 0.64 and 0.24 µM, respectively); reduces PGE2- and LTB4-induced ear swelling in mice at 50 mg/kg

Storage Temperature:

-20°C

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