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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
903895-98-7
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
384.9
Alternative Names:
n-(4-chlorophenyl)-n′-[2,3-dihydro-1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-1h-pyrazol-4-yl]-urea, fpr agonist 43
- Data sheet: View or download
- MSDS: View or download
Product Description:
An agonist of FPR1 and FPR2; induces calcium flux in CHO cells expressing human FPR2, Gα15, and aequorin (EC50 = 0.044 µM) and in CHO-K1 cells expressing either human FPR1, human FPR2, mouse Fpr1, or mouse Fpr2, Gα16, and aequorin in a concentration-dependent manner; inhibits fMLP- or IL-8-induced neutrophil migration (IC50s = 0.64 and 0.24 µM, respectively); reduces PGE2- and LTB4-induced ear swelling in mice at 50 mg/kg
Storage Temperature:
-20°C