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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
129716-58-1
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
481.6
Alternative Names:
1-[4-[2-hydroxy-3-(5-quinolinyloxy)propyl]-1-piperazinyl]-2,2-diphenyl-ethanone
- Data sheet: View or download
- MSDS: View or download
Product Description:
A quinoline derivative and inhibitor of multidrug resistance; inhibits P-glycoprotein in a photolabeling assay at 100 µM; increases intracellular accumulation of [3H]-vincristine in HL-60R cells endogenously expressing the gene encoding MRP at 10 µM; restores susceptibility to vincristine- or doxorubicin-induced cytotoxicity in vincristine-resistant P388, vincristine-resistant K562, and doxorubicin-resistant K562 cells; increases survival in a vincristine-resistant P388 murine leukemia model compared with untreated controls at 80 mg/kg twice per day when administered in combination with vincristine
Storage Temperature:
-20°C