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Corynoline

Supplier:
Catalogue number:
CAY30712-1 mg
Size:
1 mg
Product is available in:
  • UK
  • Ireland
  • Europe
  • USA
  • Rest of World
£49.00 Estimated delivery Fri 18 Jun
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An isoquinoline alkaloid with diverse biological activities; an inhibitor of acetylcholinesterase (IC50 = 30.6 µM); an inhibitor of BACE1 (IC50s = 33.59 and 89.07 µM for FRET and immobilised enzyme reactive assays, respectively); decreases LPS-induced NF-κB activation and reverses LPS-induced decreases in Nrf2 and HO-1 protein levels in HUVECs; increases the survival rate in a mouse model of LPS- and heat-killed E. coli-induced sepsis at 10, 20, and 40 mg/kg; selectively inhibits proliferation of B16/F10 mouse and A375 human melanoma cells (IC50s = 12.87 and 10.47 µM, respectively) over non-cancerous melanocytes (IC50 = 126.61 µM); reduces tumor growth in a B16/F10 mouse melanoma model at 20 mg/kg

Product Type:

Biochemicals

CAS Number:

18797-79-0

Alternative Names:

(5br,6s,12br)-5b,6,7,12b,13,14-hexahydro-5b,13-dimethyl-[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol, (+)-corynoline, (d)-corynoline, 13-methyl-chelidonine, crl

Storage Temp:

-20°C

Formulation:

A crystalline solid

Compound Purity:

≥95%

UNSPSC Code:

12352200

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