SNX-482 (ammonium salt)
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≥98%
A solid
4495
glycyl-l-valyl-l-α-aspartyl-l-lysyl-l-alanylglycyl-l-cysteinyl-l-arginyl-l-tyrosyl-l-methionyl-l-phenylalanylglycylglycyl-l-cysteinyl-l-seryl-l-valyl-l-asparaginyl-l-α-aspartyl-l-α-aspartyl-l-cysteinyl-l-cysteinyl-l-prolyl-l-arginyl-l-leucylglycyl-l-cyste
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- MSDS: View or download
A peptide class E/R-type calcium channel blocker (IC50 = 30 nM in 192C cells expressing human class E channels); selective for class E/R-type over class A and class B calcium channels (IC50s = >280 and ~800 nM, respectively), as well as the voltage-gated potassium channels Kv1.1, Kv1.2, and Kv1.4 (IC50s = >140 nM for all); inhibits class E/R-type calcium currents in isolated rat posterior pituitary (IC50 = 4 nM); intrathecal administration inhibits formalin-induced NK1 receptor internalization and cfos expression in the ipsilateral dorsal horn and reduces formalin-induced paw flinching in rats at 0.5 µg/animal
-20°C