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BIBF 1120 (esylate)

Supplier:
Catalogue number:
CAY31082-50 mg
Size:
50 mg
Product is available in:
  • UK
  • Ireland
  • Europe
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  • Rest of World
£49.00 Estimated delivery Fri 18 Jun
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A VEGFR, FGFR, and PDGFR inhibitor (IC50s = 13-34, 37-610, 59, and 65 nM for VEGFR1-3, FGFR1-4, PDGFRα, and PDGFRβ, respectively); selective for VEGFR, FGFR, and PDGFR over a panel of 33 kinases but does inhibit FLT3, LCK, LYN, and Src (IC50s = 16-156 nM); inhibits growth factor-dependent proliferation of HUVECs, HSMECs, HUASMCs, and BRPs (EC50s = 7-290 nM); reduces tumor microvessel density and the number of PDGFRβ-expressing perivascular cells in a FaDu head and neck small cell carcinoma mouse xenograft model at 100 mg/kg; inhibits tumor growth in a Caki-1 renal cancer mouse xenograft model

Product Type:

Biochemicals

CAS Number:

656247-18-6

Alternative Names:

(3z)-2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1h-indole-6-carboxylic acid, methyl ester, monoethanesulfonate, nintedanib

Storage Temp:

-20°C

Formulation:

A solid

Compound Purity:

≥98%

UNSPSC Code:

12352200

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