£414.00
Estimated delivery Tue 9 Apr
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1914078-41-3
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
510.6
Alternative Names:
n-[4-[4-amino-1-[2-[4-(dimethylamino)-1-piperidinyl]ethyl]-1h-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-carbamic acid, 1,1-dimethylethyl ester
Product Description:
An inhibitor of Src kinases (IC50s = 50 = 479 nM), as well as KIT, mTOR, PDGFRα, and RET (IC50s = >100 µM for all); completely inhibits Src and FAK phosphorylation at 100 nM; inhibits proliferation of MCF-7 cells (EC50 = 9 nM); reduces levels of activated Src kinase in tumor tissue in an HCT116 mouse xenograft model at 50 mg/kg per day
Storage Temperature:
-20°C