£203.00
Estimated delivery Fri 26 Apr
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
175414-77-4
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
401.4
Alternative Names:
1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid, sns-595, voreloxin
- Data sheet: View or download
- MSDS: View or download
Product Description:
A topoisomerase II inhibitor; induces relaxation of supercoiled DNA (IC50 = 3.2 µg/ml); induces DNA double-strand breaks in CCRF-CEM cells and cell cycle arrest at the G2 phase in A549 cells in a concentration-dependent manner; inhibits proliferation in a panel of 15 cancer cell lines, including cancer cells resistant to doxorubicin, etoposide, or cisplatin (IC50s = 0.04-1.15 µM); inhibits tumor growth in multidrug-resistant SBC-3/ETP or PC-14/CDDP mouse xenograft models at 20 mg/kg
Storage Temperature:
-20°C