£42.00
Estimated delivery Tue 9 Apr
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1477482-50-0
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
282.3
Alternative Names:
4,5,6,7-tetrahydro-1h-indazole-3-carboxylic acid (2e)-2-[(4-methylphenyl)methylene]hydrazide, sml1493
Product Description:
An inhibitor of tubulin polymerization (IC50 = 0.38 µM) with anticancer activit; inhibits the proliferation of HeLa, Jurkat, SNU-16, MDA-MB-231, A549, SH-SY5Y, HCT15, and KB-3-1 cells (IC50s = 83-381.2 nM) and P-glycoprotein-enriched KB-VI cells (IC50 = 215.7 nM); increases phosphorylation of JNK and Bcl-2 and induces apoptosis and cell cycle arrest at the G2/M phase in HeLa cells at 10 µM; reduces tumor growth in an HCT15 colon adenocarcinoma mouse xenograft model at 20 mg/kg
Storage Temperature:
-20°C