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Suprafenacine

Supplier:
Catalogue number:
CAY31158-1 mg
Size:
1 mg
Product is available in:
  • UK
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£32.00 Estimated delivery Tue 29 Jun
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An inhibitor of tubulin polymerisation (IC50 = 0.38 µM) with anticancer activit; inhibits the proliferation of HeLa, Jurkat, SNU-16, MDA-MB-231, A549, SH-SY5Y, HCT15, and KB-3-1 cells (IC50s = 83-381.2 nM) and P-glycoprotein-enriched KB-VI cells (IC50 = 215.7 nM); increases phosphorylation of JNK and Bcl-2 and induces apoptosis and cell cycle arrest at the G2/M phase in HeLa cells at 10 µM; reduces tumor growth in an HCT15 colon adenocarcinoma mouse xenograft model at 20 mg/kg

Product Type:

Biochemicals

CAS Number:

1477482-50-0

Alternative Names:

4,5,6,7-tetrahydro-1h-indazole-3-carboxylic acid (2e)-2-[(4-methylphenyl)methylene]hydrazide, sml1493

Storage Temp:

-20°C

Formulation:

A solid

Compound Purity:

≥98%

UNSPSC Code:

12352200

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