£251.00
Estimated delivery Tue 30 Apr
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1260181-14-3
Purity:
≥95%
Formulation:
A solid
Molecular Weight:
526.5
Alternative Names:
3-[5-[4-(2-hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1h-indol-3-yl)-1h-pyrrole-2,5-dione, nibr3049
- Data sheet: View or download
- MSDS: View or download
Product Description:
A JAK3 inhibitor (IC50 = 8 nM); selective for JAK3 over JAK1, JAK2, and TYK2 (IC50s = 1,017, 2,550, and 8,055 nM, respectively) but does inhibit GSK-3β, PKCα, and PKCθ (IC50s = 13, 68, and 3 nM, respectively); inhibits cytokine-induced STAT5 phosphorylation in CTLL and M-07 cells (IC50s = 1,294 and 525 nM, respectively) and TCR/CD28-mediated T cell activation in Jurkat cells (IC50 = 689 nM); increases proliferation of mouse embryonic NPCs and human iPSC-derived NPCs in the absence of BMP7 at 0.3 µM
Storage Temperature:
-20°C