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TCS 21311

Supplier:
Catalogue number:
CAY30063-5 mg
Size:
5 mg
Product is available in:
  • UK
  • Ireland
  • Europe
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£197.00 Estimated delivery Tue 22 Jun
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A JAK3 inhibitor (IC50 = 8 nM); selective for JAK3 over JAK1, JAK2, and TYK2 (IC50s = 1,017, 2,550, and 8,055 nM, respectively) but does inhibit GSK-3β, PKCα, and PKCθ (IC50s = 13, 68, and 3 nM, respectively); inhibits cytokine-induced STAT5 phosphorylation in CTLL and M-07 cells (IC50s = 1,294 and 525 nM, respectively) and TCR/CD28-mediated T cell activation in Jurkat cells (IC50 = 689 nM); increases proliferation of mouse embryonic NPCs and human iPSC-derived NPCs in the absence of BMP7 at 0.3 µM

Product Type:

Biochemicals

CAS Number:

1260181-14-3

Alternative Names:

3-[5-[4-(2-hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1h-indol-3-yl)-1h-pyrrole-2,5-dione, nibr3049

Storage Temp:

-20°C

Formulation:

A solid

Compound Purity:

≥95%

UNSPSC Code:

12352200

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TCS 21311 CAY30063-1 mg · Cayman Chemical
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