£445.00
Estimated delivery Wed 1 May
Shipping is calculated in checkout
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1111556-37-6
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
322.4
Alternative Names:
n1-(1-propyl-1h-benzimidazol-2-yl)-1,3-benzenedicarboxamide
- Data sheet: View or download
- MSDS: View or download
Product Description:
A TAK1 inhibitor (IC50 = 9.5 nM); selective for TAK1 over IRAK1, IRAK4, GCK, Clk2, and MINK1 (IC50s = 390, 120, 430, 430, and 1,900 nM, respectively); increases caspase-3/-7 activity and inhibits proliferation of TNF-α-stimulated, but not unstimulated, MDA-MB-231 cells; reduces phosphorylation of IKK, p38 MAPK, MAPK8, MAPK9, and c-Jun in TNF-α-stimulated MDA-MB-231 cells; inhibits IL-6 secretion in TNF-α-stimulated rheumatoid arthritis fibroblast-like synoviocytes; reduces inflammation and cartilage damage in knee joints in a mouse model of collagen type II-induced arthritis at 50 mg/kg per day
Storage Temperature:
-20°C