£544.00
Estimated delivery Fri 3 May
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
148451-96-1
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
472.4
Alternative Names:
n-acetyl-l-tryptophan [3,5-bis(trifluoromethyl)phenyl]methyl ester
- Data sheet: View or download
- MSDS: View or download
Product Description:
An NK1 receptor antagonist (IC50 = 1.6 nM in CHO cells expressing the human receptor); selective for NK1 over NK2 and NK3 receptors (IC50s = >5,000 nM for both); inhibits the growth of COLO 858, MEL HO, and COLO 679 melanoma cells (IC50s = 44.6, 76.3, and 64.2 µM, respectively), as well as induces apoptosis in these cell lines; inhibits plasma extravasation induced by substance P in guinea pigs (ID50 = 8 mg/kg, i.p.); attenuates mechanical allodynia and cold hyperalgesia in a rat model of neuropathic pain induce by chronic constriction injury of the sciatic nerve
Storage Temperature:
-20°C