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L-732,138

Supplier:
Catalogue number:
CAY30894-5 mg
Size:
5 mg
Product is available in:
  • UK
  • Ireland
  • Europe
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£61.00 Estimated delivery Thu 1 Jul
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An NK1 receptor antagonist (IC50 = 1.6 nM in CHO cells expressing the human receptor); selective for NK1 over NK2 and NK3 receptors (IC50s = >5,000 nM for both); inhibits the growth of COLO 858, MEL HO, and COLO 679 melanoma cells (IC50s = 44.6, 76.3, and 64.2 µM, respectively), as well as induces apoptosis in these cell lines; inhibits plasma extravasation induced by substance P in guinea pigs (ID50 = 8 mg/kg, i.p.); attenuates mechanical allodynia and cold hyperalgesia in a rat model of neuropathic pain induce by chronic constriction injury of the sciatic nerve

Product Type:

Biochemicals

CAS Number:

148451-96-1

Alternative Names:

n-acetyl-l-tryptophan [3,5-bis(trifluoromethyl)phenyl]methyl ester

Storage Temp:

-20°C

Formulation:

A crystalline solid

Compound Purity:

≥98%

UNSPSC Code:

12352200

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