£42.00
Estimated delivery Wed 1 May
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1398583-31-7
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
428.5
Alternative Names:
3-[[[(1r)-1-(4-fluorophenyl)ethyl](3-quinolinylcarbonyl)amino]methyl]-benzoic acid
- Data sheet: View or download
- MSDS: View or download
Product Description:
A TRPM8 antagonist (IC50 = 103 nM for inhibition of voltage-activated currents in HEK293 cells expressing the human receptor); >100-fold selective for TRPM8 over a panel of 90 receptors, ion channels, and enzymes; inhibits cold- and WS-12-induced calcium flux in HEK293 cells expressing the human TRPM8 (IC50s = 480 and 181 nM, respectively); reverses cold-induced reductions in bladder capacity in anesthetized guinea pigs when administered as an i.v. infusion at 46.67 µg/kg per minute; decreases the core body temperature in rats at 100 and 300 mg/kg
Storage Temperature:
-20°C