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MSA-2

Supplier:
Catalogue number:
CAY30140-500 ug
Size:
500 µg
Product is available in:
  • UK
  • Ireland
  • Europe
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  • Rest of World
£156.00 Estimated delivery Fri 18 Jun
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A STING agonist; binds to wild-type and HAQ variant STING in a 3H-cGAMP filtration binding assay (EC50s = 2.48 and 1.72 µM, respectively); induces secretion of IFN-β from THP-1 cells by 129% relative to induction by 2’3’-cGAMP at 30 µM; reduces tumor growth in an MC-38 syngeneic mouse model of colon carcinoma in a dose-dependent manner and induces tumor regression at 450 µg, intratumorally, and 50 mg/kg, s.c.; acts synergistically with an anti-PD-1 antibody in MC-38, CT26, B16/F10, and LL/2 syngeneic mouse models

Product Type:

Biochemicals

CAS Number:

129425-81-6

Alternative Names:

5,6-dimethoxy-γ-oxo-benzo[b]thiophene-2-butanoic acid

Storage Temp:

-20°C

Formulation:

A crystalline solid

Compound Purity:

≥98%

UNSPSC Code:

12352200

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