£130.00
Estimated delivery Fri 3 May
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
129425-81-6
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
294.3
Alternative Names:
5,6-dimethoxy-γ-oxo-benzo[b]thiophene-2-butanoic acid
- Data sheet: View or download
- MSDS: View or download
Product Description:
A STING agonist; binds to wild-type and HAQ variant STING in a 3H-cGAMP filtration binding assay (EC50s = 2.48 and 1.72 µM, respectively); induces secretion of IFN-β from THP-1 cells by 129% relative to induction by 2’3’-cGAMP at 30 µM; reduces tumor growth in an MC-38 syngeneic mouse model of colon carcinoma in a dose-dependent manner and induces tumor regression at 450 µg, intratumorally, and 50 mg/kg, s.c.; acts synergistically with an anti-PD-1 antibody in MC-38, CT26, B16/F10, and LL/2 syngeneic mouse models
Storage Temperature:
-20°C