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Comprehensive Epigenetic Profiling and Screening Services
Total RNA Purification From Acid-Guanidinium-Phenol Reagents
Ion Channel Screening & Profiling Services

Potassium, Inward Rectifier Channels

Cambridge Bioscience, through our collaboration with B’SYS, offers access to screening services for the following inward rectifier potassium channel targets:

Kir2.1
Gene Name: KCNJ2
Description: The human KCNJ2 gene encodes the pore-forming subunit of Kir2.1, an inwardly rectifying potassium channel. Mutations in KCNJ2 have been linked to inherited cardiac diseases including Andersens syndrome (a form of long QT syndrome with neurologic involvement), short QT syndrome, and familial atrial fibrillation. Kir2.1 channels expressed in the heart are anti-targets in cardiac risk assessment.

Kir3.1
Gene Name: KCNJ3
Description: The human KCNJ3 gene encodes the pore-forming 3.1 subunit of heteromeric Kir3 channels. Kir3.1/Kir3.4 channels expressed in heart are linked to M2 muscarinic acetylcholine receptors that mediate vagal inhibitory control of heart rate. Kir3.1 is a potential target for treatment of atrial fibrillation.

Kir3.4
Gene Name: KCNJ5
Description: The human KCNJ5 gene encodes the 3.4 subunit of heteromeric Kir3 channels. Kir3.1/Kir3.4 channels expressed in heart are linked to M2 muscarinic acetylcholine receptors that mediate vagal inhibitory control of heart rate. Kir3.4 is a potential target for treatment of atrial fibrillation.

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To discuss an inward rectifier channel screening project with one of our specialists, please Click Here
Contact Our B'SYS Specialist, Vashu